2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE
D-Glucosamine hydrochloride
CAS: 66-84-2
Molecular Formula: C6H14ClNO5
2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE - Names and Identifiers
| Name | D-Glucosamine hydrochloride |
| Synonyms | D-Glucosae HCL Glucosamine HCL D-Glucosamine HCl D-GLUCOSAMINE HCL 2-amino-2-deoxyhexose D-(+)-GLUCOSAMINE HCL Glucosamine hydrochloride 2-ammonio-2-deoxy-D-glucose D-Glucosamine hydrochloride 2-AMINO-2-DEOXY-D-GLUCOSE HCL D(+)Glucosamine, HCl (1.04113) D(+)-GLUCOSAMINE HYDROCHLORIDE 2-AMINO-D-GLUCOSE HYDROCHLORIDE alpha-D-Glucosamine hydrochloride 2-amino-2-deoxyhexose hydrochloride 2-ammonio-2-deoxy-beta-D-glucopyranose 2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE 2-ammonio-2-deoxy-alpha-D-glucopyranose 2-DESOXY-2-AMINO-D-GLUCOSE HYDROCHLORIDE 2-AMINO-2-DEOXY-D-GLUCOPYRANOSE HYDROCHLORIDE 2-Amino-2-deoxy-D-glucopyranose hydrochloride |
| CAS | 66-84-2 |
| EINECS | 200-638-1 |
| InChI | InChI=1/C6H13NO5/c7-3-5(10)4(9)2(1-8)12-6(3)11/h2-6,8-11H,1,7H2/p+1/t2-,3-,4-,5-,6+/m1/s1 |
| InChIKey | QKPLRMLTKYXDST-LPRXMDNASA-N |
2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C6H14ClNO5 |
| Molar Mass | 215.63 |
| Melting Point | 190-194°C (dec.)(lit.) |
| Boling Point | 449.9°C at 760 mmHg |
| Specific Rotation(α) | 72.5 º (c=2, H2O, 5hrs.) |
| Flash Point | 225.9°C |
| Water Solubility | soluble |
| Solubility | Alpha type is easily soluble in water, slightly soluble in ethanol. β-type soluble in water |
| Vapor Presure | 5.53E-10mmHg at 25°C |
| Appearance | White crystal |
| Color | White |
| Merck | 14,4458 |
| BRN | 4157370 |
| Storage Condition | 2-8°C |
| Stability | Stable. Incompatible with strong oxidizing agents. Combustible. |
| Refractive Index | 72 ° (C=1, H2O) |
| MDL | MFCD00135831 |
| Physical and Chemical Properties | Melting point 190-194°C specific optical rotation 72.5 ° (c = 2, H2O, 5hrs.) water-soluble solution |
| Use | Can be made into the treatment of rheumatoid arthritis, ulcers, enteritis drugs, food and cosmetics nutrition additives, biochemical cell culture agent |
2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE - Risk and Safety
| Risk Codes | R21 - Harmful in contact with skin R36/38 - Irritating to eyes and skin. R46 - May cause heritable genetic damage R62 - Possible risk of impaired fertility R63 - Possible risk of harm to the unborn child |
| Safety Description | S24/25 - Avoid contact with skin and eyes. S53 - Avoid exposure - obtain special instructions before use. S36/37 - Wear suitable protective clothing and gloves. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S25 - Avoid contact with eyes. |
| WGK Germany | 2 |
| RTECS | LZ6665000 |
| FLUKA BRAND F CODES | 3-10 |
| TSCA | Yes |
| HS Code | 29329985 |
| Hazard Note | Highly Flammable |
2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE - Reference
| Reference Show more | 1. Xie Jing, Yin Yi, donated to Yang, Liu-Cheng, et al. Optimization of enzymatic extraction of chondroitin sulfate from goose whole bone by response surface methodology [J]. Meat study 2018 32(08):40-45. 2. Lu Hua-Ding, Lian Li-yi, Chen Ming-wei, et al. Cloning and expression of an endochitosanase gene from Aspergillus in E. Coli [J]. Chinese Journal of Tissue Engineering Research, 2014, 18(034):5490-5496. 3. Shang Xiaohui, Qu Chenlong, Zhang Jianpeng, etc. Extraction of polysaccharides from sea urchin shells and analysis by high performance liquid chromatography with pre-column derivatization with PMP [J]. Shi-zhen, National Medicine, 2015(04):830-832. 4. Chen Shanglong, Liu Enqi, Chen Anhui, et al. Preliminary analysis of selenium speciation and bioavailability in two selenium-enriched products using in vitro biomimetic model [J]. Food Science, 2018, 039(004):225-232. 5. Chen Shanglong, Chen Anhui, Liu Hui, etc. Analysis of the effect of yogurt fermentation on calcium speciation by using digestive system full bionic model [J]. Journal of Agricultural Engineering, 2018, v.34;No.332(05):297-302. 6. Wang Yuan, Wu, Mengqi, Zhang, Wenqing, et al. Study on fingerprint of Lycium barbarum polysaccharides by HPLC combined with Chemometrics [J]. Chinese herbal medicine, 42 Vol. 7, page 2020-1577 MEDLINE microscopic PKU. 7. Gong Reze, Wang Yanhua, Qi Yili, etc. Effects of different processing methods on water-soluble polysaccharide content and monosaccharide composition in pilose antler [J]. Chromatography, 2019, 37(02):82-88. 8. Wang Junhua, Zhao shuangzhi, Chen Xiangyan, Zhang Yanhao, Xin Xue, Zhang Xiang, Chen Lei Lei. Antifungal activity of chitosan hydrolysates [J]. Chinese Journal of Nuclear-Agricultural Sciences, 2021,35(03):660-666. 9. Liu Songxin, Gong Ruize, Wang zeshuai, Zhang Lei, Liu Chang, Lu Yushun, Sun Yinshi. Comparative study on 9 kinds of chemical constituents of pilose antler and pilose antler based on principal component analysis and discriminant analysis [J]. Chinese herbal medicine, 2021,52(01):82-90. 10. [IF = 5.396] Fangzhou Yuan et al."Impacts of glucose and transglutaminase-catalyzed glucose with glucosamine on the conformational structure and allergenicity of bovine beta-lactoglobin." Food Funct. 2018 Jul;9(7):3944-3955 11. [IF = 6.953] Yan Zhou et al."Structural characterization and immunomodulatory activities of two polysaccharides from Rehmanniae Radix Praeparata."Int J Biol Macromol. 2021 Sep;186:385 12. [IF=6.331] Zhuoxin Chen et al."Heterogenous hydrogel mimicking the osteochondral ECM applied to tissue regeneration."J Mater Chem B. 2021 Sep ;: |
2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE - Introduction
Glucosamine is a kind of amino sugar, which is the precursor of hexosamine biosynthetic pathway, which can lead to the formation of UDP-N-acetyl glucosamine (UDP-GlcNAc), which is then used to prepare glycosaminoglycans, proteoglycans and glycolipids. D-(+)-glucosamine inhibits the co-aggregation of Candida yeast strains with a bacterial strain of Streptococcus sialicus. D-(+)-glucosamine hydrochloride has been used as a standard for quantifying and expressing chitin content in glucosamine equivalents. Cells were stimulated with glucose in the presence of glucosamine.
Last Update：2022-10-16 17:27:47
2-AMINO-2-DEOXY-D-GLUCOSE HYDROCHLORIDE - Reference Information
| EPA chemical substance information | information provided by: ofmpeb.epa.gov (external link) |
| trait | white crystalline powder |
| uses | glucosamine hydrochloride can be made into the treatment of rheumatoid arthritis, ulcers, enteritis drugs, food and cosmetics nutrition additives, culture agent for Biochemical cells. can be made into the treatment of rheumatoid arthritis, ulcers, enteritis drugs, food and cosmetic nutrition additives, glucosamine hydrochloride is extracted from natural chitin, which is a marine biological agent, which can promote the synthesis of human mucopolysaccharide and improve the viscosity of joint synovial fluid, can improve the metabolism of articular cartilage; Has the effect of promoting the injection efficiency of antibiotics, for the synthesis of water-soluble anticancer drug chloruramycin, which has the anti-cancer of nitrosourea compounds, at the same time, it has the characteristics of inhibiting bone marrow toxicity, and shows certain curative effect on melanoma, lung cancer, renal cancer, etc. Supplementation of glucosamine medium can enhance the N-glycosylation of secreted proteins, as well as variations in cell lines that affect cells such as loop cells and stem cells; Glucosamine, an amino sugar, is a precursor to the biosynthetic pathway for hexosamine, leading to the formation of UDP-N-Acetylglucosamine (UDP-GlcNAc), subsequently used for biochemical studies. Glucosamine hydrochloride is extracted from natural chitin, is a marine biological agent, is the main component of chondroitin sulfate. |
Last Update：2024-04-09 15:16:52
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